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Immunoenzymatic colorimetric method for the quantitative determination of CA 15-3 concentration in human serum or plasma. CA 15-3 ELISA is intended for laboratory use only.
CA-15-3, is an abbreviation for cancer antigen 15-3. CA 15-3 levels are most useful in following the course of treatment in women diagnosed with breast cancer, especially advanced breast cancer. CA 15-3 levels are rarely elevated in women with early stage breast cancer. Cancers of the ovary, lung and prostate may also raise CA 15-3 levels. Elevated levels of CA 15-3 may be associated with non-cancerous conditions, such as benign breast or ovarian disease, endometriosis, pelvic inflammatory disease and hepatitis.
Pregnancy and lactation can also cause CA 15-3 levels to rise. CA 15-3 is most useful for monitoring patients postoperatively for recurrence, particularly for metastatic diseases. 96% of patients with local and systemic recurrence have elevated CA 15-3, which can be used to predict recurrence earlier than radiological and clinical criteria. A 25% increase in the serum CA 15-3 is associated with progression of carcinoma. A 50% decrease in serum CA 15-3 is associated with response to treatment. CA 15-3 is more sensitive than CEA in early detection of breast cancer recurrence.
In combination with CA-125, CA 15-3 has been shown to be useful in early detection of relapse of ovarian cancer. CA 15-3 levels are also increased in colon, lung and hepatic tumours.
Model Name:
CA 15-3
Brand:
DiaMetra
Manufacturer:
Immune Diagnostic System
Origin:
Italy
TECHNICAL DATA
Specification:
Number of tests: 96
Specification:
INCUBATION: 60+60+15 min
Specification:
SAMPLE TYPE: Serum/Plasma
Specification:
SAMPLE VOLUME: 20 µL (1:50 predilution)
Specification:
ASSAY RANGE: 15 - 240 U/mL
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